Which clinical finding would most support a diagnosis of myxedema in a patient?

• A. Elevated blood pressure
• B. Puffy face and dry skin with sluggish movements
• C. Hyperactive reflexes
• D. Heat intolerance and sweating

Answer: (B)

Myxedema reflects severe hypothyroidism, where the body's metabolism slows and mucopolysaccharides deposit in tissues, producing non-pitting edema and dry, coarse skin. The combination of a puffy face, dry skin, and sluggish, slowed movements is a classic presentation of this condition. These findings directly mirror the tissue-level changes and overall slowdown of function seen in myxedema. In contrast, signs like elevated blood pressure, hyperactive reflexes, or heat intolerance and sweating point away from hypothyroidism and toward other endocrine states, so they’re less supportive of myxedema.