In primary gonadal failure, which hormone pattern is typically observed?

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Multiple Choice

In primary gonadal failure, which hormone pattern is typically observed?

Explanation:
In primary gonadal failure, the gonads fail to produce sufficient sex steroids (estrogen or testosterone) and often have reduced inhibin output. This loss of sex steroids and inhibin removes the normal negative feedback on the pituitary, so the hypothalamic–pituitary axis increases production of both gonadotropins to try to stimulate the gonads. The result is that both FSH and LH are elevated. In contrast, problems arising from the pituitary or hypothalamus (secondary gonadal failure) would show low or inappropriately normal FSH and LH despite low sex steroids.

In primary gonadal failure, the gonads fail to produce sufficient sex steroids (estrogen or testosterone) and often have reduced inhibin output. This loss of sex steroids and inhibin removes the normal negative feedback on the pituitary, so the hypothalamic–pituitary axis increases production of both gonadotropins to try to stimulate the gonads. The result is that both FSH and LH are elevated. In contrast, problems arising from the pituitary or hypothalamus (secondary gonadal failure) would show low or inappropriately normal FSH and LH despite low sex steroids.

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