In Graves' disease, what is the typical pattern of TSH and free T4?

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Multiple Choice

In Graves' disease, what is the typical pattern of TSH and free T4?

Explanation:
Graves disease causes autoimmune stimulation of the TSH receptor, which drives overproduction of thyroid hormones. The rise in circulating free T4 (and often T3) provides negative feedback to the pituitary, so TSH is suppressed. The typical lab pattern reflects this: low or undetectable TSH with elevated free T4. This distinguishes Graves from euthyroid states (where TSH and free T4 are normal) and from hypothyroid states (where TSH is high or normal and free T4 is low).

Graves disease causes autoimmune stimulation of the TSH receptor, which drives overproduction of thyroid hormones. The rise in circulating free T4 (and often T3) provides negative feedback to the pituitary, so TSH is suppressed. The typical lab pattern reflects this: low or undetectable TSH with elevated free T4. This distinguishes Graves from euthyroid states (where TSH and free T4 are normal) and from hypothyroid states (where TSH is high or normal and free T4 is low).

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